- Prevaccination skin swabbing with alcohol does not appear to influence local skin reactions or infection (cellulitis, infectious abscess) in children receiving vaccine injections.
Why this matters
- Clinicians might consider changing protocols/strategies for vaccination practices, especially in pediatric patients for whom the swab is a cue for impending acute injection pain.
- Authors note the study was underpowered to detect a difference in incidence of skin infection.
- 170 children (85 alcohol swab; 85 control; mean age, 5.6 years).
- 58% (n=49), 54% (n=45), alcohol swab, control groups, respectively, had local skin reactions (P=.59).
- Incidence of delayed pain was 45% (n=38) vs 40% (n=33), swab, control groups, respectively (P=.47).
- No cases of cellulitis, infectious abscess occurred.
- No significant influence (P>.05) of vaccine type/formulation or frequency was observed.
- Randomized, controlled, partially blinded study evaluating alcohol effectiveness for reducing local skin reactions, infections, postvaccination in children.
- Funding: Dean’s award, others.
- Self-report bias.
- Inconclusive, unpowered.