- Patients with the chronic autoimmune liver disease primary biliary cholangitis (PBC) commonly report gastrointestinal symptoms consistent with small intestinal bacterial overgrowth (SIBO).
Why this matters
- Clinicians should systematically screen patients with PBC for SIBO.
- Researchers compared the health records of patients diagnosed with PBC and screened for SIBO with the clinical characteristics of healthy volunteers (N=98; 90.8% women; mean age, 49 [age range, 21‐88] years).
- Funding: None disclosed.
- SIBO was more prevalent in the PBC group than in healthy volunteers (32.8% vs 2.5%; P<.001>
- Patients with both PBC and SIBO had more diarrhea than those with PBC only (78.9% vs 35.9%; P<.05>
- Healthy volunteers were significantly younger than patients with PBC (mean age, 39 vs 56 years; P<.001 sibo occurs more frequently in older individuals.>