Primary biliary cholangitis: small intestinal bacterial overgrowth is common

  • Liu Chen Kiow J & al.
  • Neurogastroenterol Motil
  • 1 Aug 2019

  • International Clinical Digest
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Takeaway

  • Patients with the chronic autoimmune liver disease primary biliary cholangitis (PBC) commonly report gastrointestinal symptoms consistent with small intestinal bacterial overgrowth (SIBO).

Why this matters

  • Clinicians should systematically screen patients with PBC for SIBO.

Study design

  • Researchers compared the health records of patients diagnosed with PBC and screened for SIBO with the clinical characteristics of healthy volunteers (N=98; 90.8% women; mean age, 49 [age range, 21‐88] years).
  • Funding: None disclosed.

Key results

  • SIBO was more prevalent in the PBC group than in healthy volunteers (32.8% vs 2.5%; P<.001>
  • Patients with both PBC and SIBO had more diarrhea than those with PBC only (78.9% vs 35.9%; P<.05>

Limitations

  • Healthy volunteers were significantly younger than patients with PBC (mean age, 39 vs 56 years; P<.001 sibo occurs more frequently in older individuals.>