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Clinical Summary

Prior fragility fracture is an independent risk factor for cardiovascular events in men

Takeaway

  • Prior fragility fracture, particularly of the wrist, is associated with an increased risk for admission with ischaemic heart disease (IHD) in men.

Why this matters

  • The findings could help in risk assessment of both osteoporosis and cardiovascular disease.

Study design

  • Researchers evaluated the association between prior fracture and the risk for incident cardiovascular events in 502,637 men and women aged 40-69 years between 2006 and 2010.
  • Funding: Medical Research Council; British Heart Foundation; Arthritis Research UK.

Key results

  • Amongst men, the risk for IHD admission increased by 35% with a fragility fracture within the previous 5 years (adjusted HR [aHR], 1.35; P=.047).
  • The risk for IHD admission was strongest with the fracture of the wrist (aHR, 1.55; P=.002).
  • After age-adjustment, associations for angina-related hospitalisation followed a similar pattern in men (HR, 1.54; P=.037), but after full adjustment, the association was not statistically significant (HR, 1.64; P=.121).
  • In women, the HRs for angina were a little lower, but neither the age-adjusted nor fully adjusted relationship were statistically significant.

Limitations

  • Prior fracture ascertained by self-report.      

References


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