- Children with cow’s milk allergy (CMA) as infants may have reduced risk for functional gastrointestinal disorders (FGIDs) later in life if treated with a combination of extensively hydrolysed casein formula (EHCF) and the probiotic Lactobacillus rhamnosus GG (LGG).
- Researchers report reduced functional dyspepsia, constipation, and abdominal pain.
Why this matters
- This simple dietary intervention, if validated in larger trials, could present a possible low-cost preventative for later, potentially chronic gastrointestinal conditions.
- Researchers examined children with a history of CMA during the first year of life who subsequently outgrew it ≥12 months before the study period (n=220 plus 110 consecutive healthy controls).
- They treated patients with either EHCF alone or in combination with LGG.
- Funding: Italian Ministry of Health; Mead Johnson Nutrition.
- EHCF+LGG group developed ≥1 FGID at a significantly lower rate than the EHCF group (40% vs 16.4%; P<.05>
- The FGID incidence rate ratio for the EHCF+LGG group vs the EHCF group was unchanged after correcting for age at CMA diagnosis, breastfeeding, weaning time, and first-degree relatives with 1 or more FGIDs (0.40; 95% CI, 0.25-0.65; P<.001>
- The study was single-centre, not randomised, and did not assess long-term treatment effects.
- Results may not apply to children with other food allergies or health conditions.