Prostate cancer: mycology meets oncology

  • Zhang S & al.
  • Int J Cancer
  • 4 Sep 2019

  • curated by Deepa Koli
  • Univadis Clinical Summaries
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Takeaway

  • Frequent mushroom consumption is associated with reduced risk for prostate cancer, particularly among men aged ≥50 years.

Why this matters

  • Increasing weekly mushroom intake may protect against prostate cancer.

Study design

  • 36,499 men (age, 40-79 years) from the Miyagi and Ohsaki cohort studies filled out the Food Frequency Questionnaire.
  • Funding: NARO Bio-oriented Technology Research Advancement Institution; the National Cancer Center Research and Development Fund.

Key results

  • Median follow-up, 13.2 years; total follow-up, 574,397 person-years.
  • 1204 individuals had incident prostate cancer.
  • Frequent mushroom consumption (≥3 times vs trend=.023).
  • The lower risk associated with frequent mushroom consumption was significant among patients aged ≥50 years (aHR, 0.83; 95% CI, 0.70-0.998), but not 0.98; 95% CI, 0.64-1.49).
  • The association remained significant in these patient subgroups consuming mushrooms ≥3 times weekly:
    • Vegetable and fruit consumption below median (aHR, 0.69; 95% CI, 0.48-0.98).
    • Dairy consumption above median (aHR, 0.78; 95% CI, 0.61-0.998).
    • Meat consumption above median (aHR, 0.70; 95% CI, 0.54-0.91).

Limitations

  • Only baseline mushroom consumption was reported.
  • Mushroom types were not recorded.

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