- Frequent mushroom consumption is associated with reduced risk for prostate cancer, particularly among men aged ≥50 years.
Why this matters
- Increasing weekly mushroom intake may protect against prostate cancer.
- 36,499 men (age, 40-79 years) from the Miyagi and Ohsaki cohort studies filled out the Food Frequency Questionnaire.
- Funding: NARO Bio-oriented Technology Research Advancement Institution; the National Cancer Center Research and Development Fund.
- Median follow-up, 13.2 years; total follow-up, 574,397 person-years.
- 1204 individuals had incident prostate cancer.
- Frequent mushroom consumption (≥3 times vs trend=.023).
- The lower risk associated with frequent mushroom consumption was significant among patients aged ≥50 years (aHR, 0.83; 95% CI, 0.70-0.998), but not 0.98; 95% CI, 0.64-1.49).
- The association remained significant in these patient subgroups consuming mushrooms ≥3 times weekly:
- Vegetable and fruit consumption below median (aHR, 0.69; 95% CI, 0.48-0.98).
- Dairy consumption above median (aHR, 0.78; 95% CI, 0.61-0.998).
- Meat consumption above median (aHR, 0.70; 95% CI, 0.54-0.91).
- Only baseline mushroom consumption was reported.
- Mushroom types were not recorded.