Prostate Cancer Risk Higher in Men With IBD

Takeaway

• Men with inflammatory bowel disease (IBD) are at an increased risk of incident prostate cancer (PC) compared to men without IBD.
• This association is driven by an approximate 50% increase in the risk of PC among men with ulcerative colitis (UC).

Why this matters

• Findings suggest that even outside the setting of routine PC screening, men with IBD are at a higher risk of PC.

Study design

• This prospective, population-based UK Biobank cohort study included 218,084 men (aged 40-69 years; 2,311 men with a history of IBD and 215,773 men without a history of IBD) between 2006 and 2010.
• Association between IBD and subsequent PC was evaluated.
• Funding: National Institutes of Health.

Key results

• After a median follow-up of 78 months, men with IBD were at an increased risk of PC (adjusted HR [aHR], 1.31; 95% CI, 1.03-1.67; P=.029).
• PC risk was especially increased in men with UC (aHR, 1.47; 95% CI, 1.11-1.95; P=.0070) and not Crohn’s disease (aHR, 1.06; 95% CI, 0.63-1.80; P=.82)
• Increasing HR was seen across years since:
  • IBD diagnosis:
    • ≤20 years: aHR, 1.22 (95% CI, 0.89-1.66); and
    • >20 years: aHR, 1.49 (95% CI, 1.01-2.19; P_trend=.018).
  • UC diagnosis:
    • ≤20 years: aHR, 1.29 (95% CI, 0.89-1.85); and
    • >20 years: aHR, 1.87 (95% CI, 1.21-2.91; P_trend=.0022).

Limitations

• The study was unable to account for the frequency of healthcare encounters in the analysis of incident PC.
• UK Biobank data did not provide information regarding cancer grade or stage.

Meyers TJ, Weiner AB, Graff RE, Desai AS, Cooley LF, Catalona WJ, Hanauer SB, Wu JD, Schaeffer EM, Abdulkadir SA, Kundu SD, Witte JS. Association between inflammatory bowel disease and prostate cancer: A large-scale, prospective, population-based study. Int. J. Cancer. 2020 May 13 [Epub ahead of print]. doi: 10.1002/ijc.33048. PMID: 32399975. View abstract

This clinical summary first appeared on Univadis, part of the Medscape Professional Network.