- Dipstick proteinuria and reduced estimated glomerular filtration rate (eGFR) are independent risk factors for osteoporosis.
- Proteinuria is known to contribute to vitamin D deficiency and dysfunction of osteoblasts, but the biological rationale for lower eGFR and osteoporosis is unknown.
Why this matters
- Patients with these risk factors may warrant more frequent osteoporosis screening.
- Cross-sectional cohort of 21,271 participants in a community-based health survey in Taiwan.
- Positive proteinuria was presence of 1+ or more urinary proteins on the dipstick (≥30 mg/dL).
- eGFR was categorized into tertiles (highest was ≥60 mL/minute/1.73 m2, middle was ≥30 to <60 mL/minute/1.73 m2, and lowest was <30 mL/minute/1.73 m2).
- Osteoporosis was defined by a T-score of ≤−2.5, measured by calcaneal quantitative ultrasound.
- Funding: Chiayi County Health Bureau, Taiwan.
- On multivariate analysis, participants with 1+ proteinuria were at 15% higher risk for osteoporosis (aOR, 1.15; 95% CI, 1.02-1.32) and those with ≥2+ proteinuria (>100 mg/dL) were at 18% higher risk (aOR, 1.18; 95% CI, 1.05-1.33).
- Participants in the middle and lowest eGFR tertiles (relative to the highest tertile) were at higher risk for osteoporosis (aORs, 1.31 [95% CI, 1.20-1.44] and 2.46 [95% CI, 1.73-3.48], respectively).
- Cross-sectional design.