Psoriasis: adalimumab found generally safe in meta-analysis

  • Guan X & al.
  • J Cosmet Dermatol
  • 4 Feb 2019

  • curated by Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • A systematic review and meta-analysis suggest that adalimumab (Humira) is associated with a higher incidence of adverse events (AEs), but not serious AEs or discontinuation in patients with psoriasis.

Why this matters

  • Robust safety information can help guide treatment decisions.

Key results

  • Adalimumab was associated with higher incidence of AEs (15 trials; relative risk [RR], 1.05; 95% CI, 1.00-.109), infection (14 trials; RR, 1.10; 95% CI, 1.02-1.20), and injection site reaction (6 trials; RR, 1.80; 95% CI, 1.18-2.74) compared with control treatment.
  • Adalimumab and control treatment were associated with similar incidence of serious AEs (16 trials; RR, 1.06; 95% CI, 0.70-1.48), serious infection (9 trials; RR, 1.22; 95% CI, 0.61-2.44), and discontinuation caused by AE (13 trials; RR, 1.12; 95% CI, 0.80-1.57).
  • No significant publication bias was observed by Egger’s test (P=.299).

Study design

  • Patients with psoriasis, 3917 treated with adalimumab and 2583 control patients, from 20 RCTs were included in this meta-analysis of clinical safety.
  • Funding: None disclosed.

Limitations

  • Heterogeneity between included studies.

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