- Psoriasis was independently associated with a small but increased risk of serious infection.
- People with psoriasis had an increased risk of hospitalisation because of any infection; respiratory infections; soft tissue and skin infections.
- Mortality risk because of any infection was also higher in people with psoriasis vs those without.
Why this matters
- Findings warrant future studies to understand how psoriasis predisposes to a higher risk of infection.
- A cohort study included 69,315 patients with psoriasis and 338,620 matched comparators using the UK Clinical Practice Research Datalink (CPRD).
- Funding: None disclosed.
- Patients with psoriasis had a higher incidence rate of serious infection compared with those without psoriasis (20.5 [95% CI, 20.0-21.0] vs 16.1 [95% CI, 15.9-16.3] per 1000 person-years).
- After adjustment for potential confounders, patients with psoriasis vs those without were at an increased risk for hospitalisation because of:
- any infection (HR, 1.36; 95% CI, 1.31-1.40);
- respiratory infections (HR, 1.35; 95% CI, 1.27-1.44); and
- skin and soft-tissue infections (HR, 1.56; 95% CI, 1.43-1.70).
- Similarly, patients with psoriasis had an increased risk for death because of any infection (HR, 1.33; 95%CI, 1.08-1.63).
- Potential risk of residual confounding and detection bias.