New research suggests people with psoriasis could have a higher risk of cancer incidence and cancer-related mortality.
For the study, published in JAMA Dermatology, researchers conducted a systematic review and meta-analysis of 58 observational studies exploring the risk of cancer incidence and mortality in people with psoriasis.
They found severe psoriasis (RR 1.22; 95% CI 1.08-1.39 [9 studies]) and all severities of psoriasis (RR 1.18; 95% CI 1.06-1.31 [7 studies]) were associated with an increased risk of cancer. The study also identified associations for a range of site-specific cancers, including colon, colorectal, kidney, laryngeal, liver, oral and pancreatic cancer, as well as lymphoma and squamous cell carcinoma.
Overall cancer mortality risk was also higher in patients with severe psoriasis (RR 1.22; 95% CI 1.08-1.38 [4 studies]). Specifically, liver, oesophageal and pancreatic cancer mortality were found to be elevated in those with severe psoriasis.
“These findings suggest that cancer is an important comorbidity in people with psoriasis, and dermatologists should be aware of this increased risk. Further studies are needed to improve our knowledge about the underlying mechanisms of this increased risk,” the authors concluded.