Individuals with psoriasis may have an increased risk for chronic kidney (CKD) and end-stage renal disease (ESRD), according to a meta-analysis published in the journal International Urology and Nephrology.
Researchers conducted a meta-analysis of 4 retrospective cohort studies identified through a literature search on the MEDLINE and EMBASE databases.
The pooled analysis of 4 studies showed a significantly increased risk for incident CKD in patients with psoriasis (risk ratio [RR], 1.34; 95% CI, 1.14-1.57). Similarly, patients with psoriasis were also found to have a significantly increased risk for ESRD (RR, 1.29; 95% CI, 1.05-1.60) in a pooled analysis of 3 studies. The risk for CKD remained significant even after exclusion of 1 study in the sensitivity analysis that did not adjust its effect estimate for potential confounders.
According to the authors, psoriasis is likely to be an independent risk factor for CKD/ESRD, and the increased risk cannot be solely attributed to the higher prevalence of metabolic and cardiovascular comorbidity or use of nephrotoxic drugs among patients with psoriasis.
Some of the possible mechanisms underlying the association include accelerated atherosclerotic injury to kidneys, psoriasis-induced inflammatory damage to the kidneys and coexistence of IgA nephropathy in patients with psoriasis.