Takeaway
- People with psoriatic disease are at greater risk for incident thyroid diseases including hyperthyroidism, hypothyroidism, thyroiditis, and specific autoimmune thyroid disease (Grave’s disease and Hashimoto’s thyroiditis).
Why this matters
- Findings may be helpful in risk stratification for thyroid disease in patients with psoriatic disease.
- Endocrinological consultation may be offered to patients with psoriasis with thyroid symptoms.
Study design
- Study of 13,266 patients with psoriatic arthritis (mean age, 43.17 years), 149,576 with psoriasis alone (mean age, 45.11 years), and 162,842 without psoriasis (mean age, 44.95 years).
- Funding: Far Eastern Memorial Hospital, Taiwan.
Key results
- Compared with individuals without psoriasis, those with psoriasis arthritis and psoriasis had increased risk for:
- incident hyperthyroidism: aHR, 1.32 (95% CI, 1.07-1.65) and 1.22 (95% CI, 1.11-1.33), respectively;
- incident hypothyroidism: aHR, 1.74 (95% CI, 1.34-2.27) and 1.38 (95% CI, 1.23-1.56), respectively;
- thyroiditis: aHR, 2.05 (95% CI, 1.51-2.77) and 1.42 (95% CI, 1.22-1.64), respectively;
- Grave’s disease: aHR, 1.38 (95% CI, 1.07-1.79) and 1.26 (95% CI, 1.13-1.41), respectively;
- Hashimoto’s thyroiditis: aHR, 2.09 (95% CI, 1.34-3.24) and 1.47 (95% CI, 1.18-1.82), respectively.
Limitations
- Retrospective design.
- Lack of data on disease severity.
References
References