- Adding a personalized psychosocial intervention to usual care significantly improved response to maintenance opioid agonist therapy (OAT) in treatment-resistant patients vs usual care alone.
Why this matters
- Adding psychosocial intervention to usual care was also cost-effective.
- Resistance is represented by continued use of illicit or nonprescription opioids or cocaine during OAT.
- 270 patients with opioid use disorder were randomly assigned to usual care with or without a psychosocial intervention.
- Funding: Indivior.
- At week 18, the treatment response rate was higher with psychosocial intervention vs standard care alone (16% vs 7%; adjusted log odds, 1.20; P=.048).
- The probability of treatment response was significantly higher with psychosocial intervention (average marginal effect, 0.108; P=.025).
- The probability that the psychosocial intervention was cost-effective ranged from 47% to 87% at a threshold of £0-£1000 per unit improvement.
- Quality-adjusted life years (QALYs) were higher in the psychosocial intervention (adjusted mean difference, 0.048; P=.004).
- The probability of the psychosocial intervention being cost-effective was 60% and 67% at National Institute for Health and Care Excellence willingness-to-pay thresholds of £20,000 and £30,000 per QALY, respectively.
- The number of adverse events was similar between groups.
- 1 participant in the standard care group died.
- Open-label design.
Coauthored with Antara Ghosh, PhD