- People with pulmonary embolism (PE) are at risk for psychiatric disorders, including dementia, anxiety, depression, and sleep disorders, according to a nationwide cohort.
Why this matters
- Clinicians should consider monitoring patients with PE for psychiatric disorders.
- Mechanistic basis of link may trace to brain hypoxia with PE.
- Retrospective population-based nationwide cohort (n=21,916 patients ≥20 years old with PE in 2000-2015 were compared with 65,748 control individuals without PE matched for sex and age) in the National Health Insurance Research Database of Taiwan.
- Funding: Tri-Service General Hospital Research Foundation; others.
- People with PE had a 70% increased risk for psychiatric disorders (aHR, 1.704; P<.001 including the following specific disorders:>
- 56% increased risk for dementia (aHR, 1.563; P<.001>
- 85% increased risk for anxiety (aHR, 1.854; P<.001>
- 2-fold increased risk for depression (aHR, 2.040; P<.001>
- Nearly 60% increased risk for sleep disorders (aHR, 1.597; P<.001>
- No increased risk for bipolar or psychotic disorders.
- Reliance on health claims.
- Findings may be limited to Asians.