R/R MM: HDAC inhibitor achieves response in combination with bortezomib and dexamethasone

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Takeaway

  • Ricolinostat 160 mg/d in combination with bortezomib and dexamethasone was well tolerated and delivered promising efficacy in patients with relapsed/refractory (R/R) multiple myeloma (MM).

Why this matters

  • Resistance to proteasome inhibition is inevitable leading to disease progression.
  • Ricolinostat is a selective histone deacetylase (HDAC6) inhibitor which may offer anti-myeloma efficacy in combination with proteasome inhibition.

Study design

  • Phase 1/2 study to investigate ricolinostat in 72 patients with R/R MM.
  • Patients were assigned to 5 ricolinostat monotherapy cohorts and 9 dose cohorts in combination with bortezomib and dexamethasone.
  • Funding: Acetylon Pharmaceuticals, Inc.

Key results

  • No patients achieved response with ricolinostat monotherapy.
  • Overall 29% response with combination therapy; 39% clinical benefit...