- Age, sex, race, insurance status, and extent of surgery are associated with postsurgical radioactive iodine (RAI) ablation in patients with low-risk papillary thyroid cancer (PTC).
Why this matters
- Postsurgical RAI is not indicated for low-risk patients under American Thyroid Association (ATA) guidelines.
- 25% of patients with low-risk PTC received RAI.
- Risk factors for postsurgical RAI in low-risk PTC:
- Male sex (OR, 1.191; 95% CI, 1.086-1.305).
- Hispanic (OR, 1.236; 95% CI, 1.110-1.376) or Asian race (OR, 1.306; 95% CI, 1.159-1.473).
- Number of lymph nodes removed (OR, 1.090; 95% CI, 1.003-1.184 for 1-3; OR, 1.243; 95% CI, 1.119-1.381 for ≥4).
- Total/near total thyroidectomy (OR, 5.823; 95% CI, 5.036-6.734).
- Black race (OR, 0.851; 95% CI, 0.733-0.987) and unknown insurance status (OR, 0.503; 95% CI, 0.374-0.676) were inversely associated with postsurgical RAI in patients with low-risk PTC.
- 32,229 patients with PTC, 53.6% classified as low risk (T1 without metastasis), were analyzed for factors associated with postsurgical RAI.
- Funding: None.
- Retrospective study of large database.