- Carbon-ion re-irradiation (CIR) is associated with 66% local control and 72% distant control in patients with rare head and neck cancers (HNCs).
Why this matters
- CIR may represent an alternative treatment to palliative systemic therapies.
- Median total dose with carbon ions was 51 Gy.
- The median interval between initial radiotherapy (RT) and CIR was 5.2 years.
- The median total tumor lifetime dose after initial RT and CIR was 128.6 Gy.
- Median local PFS was 24.2 months.
- 1-year local control was 66%.
- 1-year distant control was 72%.
- Median OS after CIR was 28.5 months for patients with an RT interval ≥2 years vs 8.9 months for patients with an RT interval
- No severe (≥grade 3) acute or late toxicities were observed after CIR.
- 32 patients with rare HNC were treated with CIR and analyzed for outcomes.
- Funding: None.
- Short follow-up (median 18.1 months).
- Small patient sample size.
- Retrospective study.