- A simplified 2-variable model accurately predicts rebound hyperbilirubinemia in infants after inpatient phototherapy.
- Model uses gestational age (GA), difference between starting/ending total serum bilirubin (TSB).
Why this matters
- Authors say that for infants
- 4.6% of infants had rebound hyperbilirubinemia.
- Area under the curve for the 2-variable model was 0.876 (95% CI, 0.854-0.899) vs 0.881 (95% CI, 0.859-0.903) with 3 variables.
- Rebound probability with phototherapy cessation at 2 mg/dL below starting threshold:
- For infants ≥38 weeks’ GA: 2.5%.
- For infants
- Score calculation: 15.5 (if GA
- Equation (can be entered as function in spreadsheet) for predicted probability of rebound: 1/(1 + exp[–(0.097 * score – 2.84)]).
- The models had a mean difference of 0 for predicting rebound.
- Retrospective cohort study, 52 infants born 2012-2014 at ≥35 weeks of gestation, 17 Kaiser Permanente hospitals.
- Infants had inpatient phototherapy before age 14 days.
- Funding: None.
- Relatively small sample.
- 15% had glucose-6-phosphate dehydrogenase deficiency.