- A study of 10 million people found that recovering from metabolic syndrome (MetS) is tied to decreased risk for major adverse cardiovascular (CV) events (MACEs).
Why this matters
- These authors say that the results offer hope to patients with MetS that getting treatment for its 5 factors can lead to decreased MACE risk.
- This study compared outcomes for people who develop vs people who recover from MetS vs other studies of people with and without MetS.
- MACE incidence rates:
- Chronic MetS: 8.52/1000 person-years.
- Developed MetS: 6.05/1000 person-years.
- Recovered from MetS: 4.55/1000 person-years.
- No MetS: 1.92/1000 person-years.
- At a median of 3.54 years:
- With MetS recovery, MACE risk (adjusted incidence rate ratio [IRR]) was 0.85 (95% CI, 0.83-0.87) vs chronic MetS.
- In those who developed MetS, adjusted IRR for MACE risk was 1.36 (95% CI, 1.33-1.39) vs having no MetS.
- Hypertension drove much of the change in MACE risk.
- National database study, Korea, covering 9,553,042 people ages 20+ years with health insurance and no MACE history, 2009-2014.
- Funding: Republic of Korea.
- Limited assessment of mortality, short follow-up, retrospective.