- Health-related QoL at baseline is a significant predictor of PFS and OS in women with potentially platinum-sensitive recurrent ovarian cancer (PPSROC; platinum-free interval >6 months) who have had 3 or more lines of chemotherapy.
Why this matters
- In the heavily treated patient, identification of the prognostic factors could help clinicians to decide whether supportive care could be better than chemotherapy.
- A gynecological cancer intergroup (GCIG) symptom benefit, prospective cohort study of 378 adult women with PPSROC≥3 chemotherapy who completed health-related QoL questionnaires.
- Funding: None disclosed.
- 45 (12%) participants stopped using chemotherapy ≤8 weeks:
- Median PFS, 1.6 (95% CI, 1.2-1.7) months.
- Median OS, 3.4 (95% CI, 1.7-7.2) months.
- Social function was a statistically significant factor for predicting PFS: aHR: 1.30 (P=.030).
- Health-related QoL domains associated (aHRs) with OS included (P<.041 style="list-style-type:circle;">
- Physical function: 1.61 (P=.011).
- Role function: 1.45 (P=.041).
- Cognitive function: 1.47 (P=.026).
- Social function: 1.83 (P<.001>
- Observational study design.
- Self-reported data.