Regular physical activity blunts triglyceride-raising effects of a high-fat meal

  • Mitchell BD & al
  • J Clin Lipidol
  • 20 Nov 2018

  • from Antara Ghosh
  • Clinical Summaries
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Takeaway

  • Regular physical activity was associated with a decrease in postprandial lipaemia after a fat meal in apparently healthy men and women.

Why this matters

  • Reduction in triglycerides after a meal and/or reducing time spent in postprandial lipaemia could be an important strategy for reducing cardiovascular risk.

Study design

  • Secondary analysis of Hereditary and Phenotype Intervention Heart Study, which measured triglyceride levels in 838 Amish individuals who were, administered a high-fat meal diet.
  • Accelerometry collected physical activity data in a subset of 671 individuals.
  • Triglyceride response to the high-fat meal was characterized as area under the curve (AUC) based on the triglyceride levels measured at 1, 2, 3, 4, and 6 hours post-fat challenge.
  • Funding: NIH.

Key results

  • Postprandial lipaemia response to high-fat diet challenge increased with increasing age in both men and women (P<.001>
  • Physical activity level was inversely correlated with fasting triglycerides levels (P≤.01).
  • After adjusting for age, sex and kinship, higher physical activity level was associated with a lower triglyceride AUC (P=.017).
  • Individuals in the lowest vs highest quartile of physical activity experienced a 17% (95% CI, 5%-29%) increase in triglyceride AUC.

Limitations

  • Results not generalisable as Amish community is characterised by relatively high levels of physical activity.