- Regular physical activity was associated with a decrease in postprandial lipaemia after a fat meal in apparently healthy men and women.
Why this matters
- Reduction in triglycerides after a meal and/or reducing time spent in postprandial lipaemia could be an important strategy for reducing cardiovascular risk.
- Secondary analysis of Hereditary and Phenotype Intervention Heart Study, which measured triglyceride levels in 838 Amish individuals who were, administered a high-fat meal diet.
- Accelerometry collected physical activity data in a subset of 671 individuals.
- Triglyceride response to the high-fat meal was characterized as area under the curve (AUC) based on the triglyceride levels measured at 1, 2, 3, 4, and 6 hours post-fat challenge.
- Funding: NIH.
- Postprandial lipaemia response to high-fat diet challenge increased with increasing age in both men and women (P<.001>
- Physical activity level was inversely correlated with fasting triglycerides levels (P≤.01).
- After adjusting for age, sex and kinship, higher physical activity level was associated with a lower triglyceride AUC (P=.017).
- Individuals in the lowest vs highest quartile of physical activity experienced a 17% (95% CI, 5%-29%) increase in triglyceride AUC.
- Results not generalisable as Amish community is characterised by relatively high levels of physical activity.