- Compared with children from high-income countries (HICs), those from low/middle-income countries (LMICs) far more often have extraocular tumors at retinoblastoma diagnosis.
- This feature is present in 49.1% of children from low-income countries (LICs) vs 1.5% from HICs.
Why this matters
- LMICs are where most retinoblastomas are diagnosed.
- This disease is curable if diagnosed early enough.
- Median age at diagnosis was 23.5 (interquartile range [IQR], 11.2-36.5) months.
- Patients from HICs were diagnosed at a median age of 14.0 (IQR, 6.2-26.6) months.
- Patients from LICs were diagnosed at a median age of 30.5 (IQR, 18.3-45.9) months.
- Children from LMICs made up the vast majority (84.7%) of the cohort.
- 98.5% of children from HICs had intraocular disease at diagnosis.
- 49.1% of children from LICs had extraocular disease, and 18.9% had metastases.
- Included 4351 patients from 278 treatment centers in 153 countries.
- Funding: Queen Elizabeth Diamond Jubilee Trust.
- Biases associated with a convenience sample.
- Largely retrospective data.