- Overall, patients with right-sided colorectal cancer (CRC) appear to have inferior survival vs those with left-sided cancer; however, stratified analysis reveals the survival difference applies only in patients with late-stage disease.
Why this matters
- A growing body of evidence suggests a link between tumor location and OS in patients with CRC.
- Study to investigate an association between right-sided and left-sided disease and survival outcomes in patients with CRC.
- Data were sourced from the Mayo Clinic Colon and Rectal Cancer Registry pertaining to 26,908 patients with colon and rectal cancer.
- Funding: None disclosed.
- 76.6 months median survival for right-sided tumors vs 93.0 for left-sided.
- Median survival by tumor location:
- 101.3 months for rectal cancers.
- 87.5 months for left-sided cancers.
- 76.6 months for right-sided cancers.
- In a multivariate Cox regression analysis model:
- No significant difference in overall mortality for left- vs right-sided disease in patients with early (stage I-III) disease: HR, 0.99; 95% CI, 0.93-1.04; P=.6443.
- Significant difference in overall mortality for left- vs right-sided disease in patients with late-stage (stage IV) disease: HR, 0.73; 95% CI, 0.67-0.80; P<.001.>
- Retrospective data.
- Study did not incorporate treatment-related variables.