- People with schizophrenia have increased risk for upper gastrointestinal bleeding (UGIB) and nonbleeding ulcers despite not having risk factors different from the general population.
- In these patients, having these conditions is tied to increased all-cause mortality.
- This cohort study involves 32 years of follow-up.
Why this matters
- These authors say that an elevated risk for UGIB, ulcers might be expected because of increased rates of substance abuse among people with schizophrenia.
- There were 459,564 person-years of follow-up.
- With schizophrenia, standardized incidence ratios (95% CIs) were:
- 2.92 (2.76-3.08) for UGIB;
- 2.36 (2.15-2.58) for bleeding ulcers; and
- 2.00 (1.87-2.15) for nonbleeding ulcers.
- No difference by sex seen, values were largely stable across age, year of diagnosis.
- Age of diagnosis >35 years was a risk factor for UGIB: adjusted HR, 2.32 (95% CI, 1.75-3.08).
- These patients were also likelier to have bleeding ulcers: adjusted HR, 8.50 (95% CI, 3.76-19.17).
- Danish registry data, patients with incident schizophrenia, 1980-2011.
- Outcomes: cumulative incidences, risk factors, all-cause mortality.
- Funding: RocheProd, Ltd., Welwyn Garden City, United Kingdom, others.
- Generalizability to other national health care settings unclear.
- Patients with schizophrenia in Denmark might be healthier than those in nations without universal health care.