- Women with schizophrenia have a 31% higher risk for breast cancer incidence than women in the general population or those without schizophrenia.
Why this matters
- Women with schizophrenia require more intensive breast cancer screening and treatment.
- A meta-analysis of 12 cohorts (n=125,760) that met eligibility criteria after search of PubMed and EMBASE databases.
- Funding: Natural Science Foundation of Tianjin, China; Tianjin Health Bureau Foundation.
- Women with schizophrenia have a 31% higher risk for breast cancer incidence (standardized incidence ratio, 1.31; P<.001) compared with women in the general population or women without schizophrenia, but with significant heterogeneity (P<.001; I2=89%).
- The association between schizophrenia and breast cancer is unaffected by whether breast cancer cases were excluded at baseline or the sample size of the included studies.
- Significant heterogeneity across studies.