Schizophrenia tied to increased breast cancer risk

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Takeaway

  • Women with schizophrenia have a 31% higher risk for breast cancer incidence than women in the general population or those without schizophrenia.

Why this matters

  • Women with schizophrenia require more intensive breast cancer screening and treatment.

Study design

  • A meta-analysis of 12 cohorts (n=125,760) that met eligibility criteria after search of PubMed and EMBASE databases.
  • Funding: Natural Science Foundation of Tianjin, China; Tianjin Health Bureau Foundation.

Key results

  • Women with schizophrenia have a 31% higher risk for breast cancer incidence (standardized incidence ratio, 1.31; P<.001 compared with women in the general population or without schizophrenia but significant heterogeneity i>2=89%).
  • The association between schizophrenia and breast cancer is unaffected by whether breast cancer cases were excluded at baseline or the sample size of the included studies.

Limitations

  • Significant heterogeneity across studies.