Schizophrenia: vitamin D supplementation may alleviate depressive and anxiety disorders

  • Fond G & al.
  • Psychiatry Res
  • 13 Sep 2018

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • Hypovitaminosis D was frequent and insufficiently treated and is associated with depressive symptoms and anxiety disorders in patients with schizophrenia.
  • Vitamin D supplementation was associated with a lower risk for depressive and anxiety symptoms.

Why this matters

  • Screening for depression and anxiety is not common in patients with schizophrenia.
  • Vitamin D supplementation may alleviate depressive symptoms and anxiety disorders.

Study design

  • Study of 140 patients with schizophrenia from French FondaMental Expert Center (FACE-SZ) cohort.
  • Hypovitaminosis D was defined by blood vitamin D level
  • Depressive symptoms were assessed by the Positive and Negative Syndrome Scale depressive subscore and current anxiety disorder by the Structured Clinical Interview for Mental Disorders.

Key results

  • 21.4% of patients had hypovitaminosis D, none of them received vitamin D supplementation in last 12 months.
  • Hypovitaminosis D showed a significant association with higher depressive symptoms (aOR, 1.18; P=.02) and current anxiety disorder (aOR, 6.18; P=.001).
  • No association of hypovitaminosis D with positive and negative symptoms, cognitive scores or other biological variables has been found (all P>.05).
  • 8.5% of the patients had vitamin D supplementation in the previous 12 months, none of them had hypovitaminosis D.
  • Vitamin D supplementation in the previous 12 months was associated with lower risk for depressive symptoms (aOR, 0.67; P=.04) and current anxiety disorder (aOR, 0.06; P=.02) vs patients with hypovitaminosis D.

Limitations

  • Small sample size.
  • Dose and duration of vitamin D supplementation were not known.

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