- Hypovitaminosis D was frequent and insuﬃciently treated and is associated with depressive symptoms and anxiety disorders in patients with schizophrenia.
- Vitamin D supplementation was associated with a lower risk for depressive and anxiety symptoms.
Why this matters
- Screening for depression and anxiety is not common in patients with schizophrenia.
- Vitamin D supplementation may alleviate depressive symptoms and anxiety disorders.
- Study of 140 patients with schizophrenia from French FondaMental Expert Center (FACE-SZ) cohort.
- Hypovitaminosis D was deﬁned by blood vitamin D level
- Depressive symptoms were assessed by the Positive and Negative Syndrome Scale depressive subscore and current anxiety disorder by the Structured Clinical Interview for Mental Disorders.
- 21.4% of patients had hypovitaminosis D, none of them received vitamin D supplementation in last 12 months.
- Hypovitaminosis D showed a signiﬁcant association with higher depressive symptoms (aOR, 1.18; P=.02) and current anxiety disorder (aOR, 6.18; P=.001).
- No association of hypovitaminosis D with positive and negative symptoms, cognitive scores or other biological variables has been found (all P>.05).
- 8.5% of the patients had vitamin D supplementation in the previous 12 months, none of them had hypovitaminosis D.
- Vitamin D supplementation in the previous 12 months was associated with lower risk for depressive symptoms (aOR, 0.67; P=.04) and current anxiety disorder (aOR, 0.06; P=.02) vs patients with hypovitaminosis D.
- Small sample size.
- Dose and duration of vitamin D supplementation were not known.