- High background parenchymal enhancement (BPE) on screening breast MRI is associated with higher abnormal interpretation rate.
- BPE, an inherent property of breast tissue, is indicative of the physiologic enhancement of normal fibroglandular tissue.
Why this matters
- Higher BPE interferes with identification of suspicious lesions, and thus impairs diagnostic performance of screening breast MRI.
- Retrospective analysis of 4686 screening breast MRIs from 2446 women.
- BPE was divided into 2 categories by radiologist rating: minimal or mild (85%) and moderate or marked (15%).
- Performance measures (e.g., abnormal interpretation rate; AIR) were compared, with adjustment for these confounders: age, screening indication, mammographic density, available prior MRI, and examination year.
- Funding: None disclosed.
- The higher (vs lower) BPE group was associated with higher AIR (13% vs 7%; adjusted OR, 1.37; 95% CI, 1.03-1.82).
- Higher (vs lower) BPE was not associated with cancer detection rate, positive predictive value, sensitivity, and specificity (all P's>.05).
- Retrospective observational study.
- Single center, with single radiologist performing ratings.