- In this analysis from the Nurses’ Health Studies, women who quit smoking ≥30 years ago had lower risk for seropositive rheumatoid arthritis (RA) than women who quit 0 to
- No such association seen with smoking and seronegative RA.
Why this matters
- These 2 large, prospective cohorts cover 38 years and more than 6 million person-years.
- Seronegative and seropositive RA may have different etiologies, risk factors.
- Vs never smoking, current smoking (adjusted HRs; 95% CIs):
- Increased risk for any RA: 1.47 (1.27-1.72).
- Increased risk for seropositive RA: 1.67 (1.38-2.01).
- Did not affect risk for seronegative RA: 1.20 (0.93-1.55).
- Among ever smokers, vs quitting
- Even with 3 decades of nonsmoking, however, these women still had slightly elevated RA risk vs never smokers (HRs, 95% CIs):
- Any RA: 1.25 (1.02-1.53);
- Seropositive RA: 1.30 (1.01-1.68).
- Seronegative RA showed no associations with smoking.
- Data from the 1976-2014 (n=117,182) and 1989-2015 (n=113,550) cohorts of the Nurses’ Health Studies.
- Funding: NIH.
- These cohorts are mostly well-educated white women who are nurses, so generalization is unclear.