- The incidence of acute hepatitis C virus (AHCV) infections is high among HIV-negative men who have sex with men (MSM) on preexposure prophylaxis (PrEP), highlighting screening needs.
Why this matters
- Regardless of HIV status, more frequent HCV screening and diagnosis and timely treatment are recommended.
- 429 participants; median follow-up duration, 2.1 (interquartile range [IQR], 1.5-2.8) years.
- 14 participants (median age, 30 [IQR, 27-35] years) diagnosed with AHCV: 1 at entry, 13 incident cases.
- HCV incidence: 1.40 (95% CI, 0.74-2.39) per 100 person-years.
- 43% (n=6), 7% (n=1), and 50% (n=7) had HCV genotypes 1a, 3a, and 4d, respectively.
- Patients with AHCV reported a median of 17 (IQR, 8-30) sexual partners in the last 2 months vs 8 (IQR, 5-16) in uninfected individuals (P=.03), and median of 18 (IQR, 12-30) sexual acts during the last 4 weeks vs 10 (IQR, 5-16) in uninfected individuals (P=.02).
- EIA HCV antigen, viral load test assays (Cobas HCV, Xpert HCV) had 100% sensitivity at diagnosis vs OraQuick (93% [95% CI, 66%-99%]), Toyo (79% [95% CI, 49%-45%]).
- Subgroup analysis assessing AHCV incidence, infection risk factors, and testing sensitivity among high-risk MSM participating in the ANRS IPERGAY PrEP trial.
- Funding: Inserm-ANRS; others
- Self-report bias.
- Sexual risk behavior analyzed at inclusion only.
- Test assay performance overestimated.
- Reinfection unassessed.