- A structured formula supplementation for at-risk neonates did not affect prevalence of breastfeeding at 6 months, but outcomes for 12 months were less positive in this randomized controlled trial .
Why this matters
- The CDC urges breastfeeding to 6 and 12 months, but only about half of US infants reach the 6-month mark.
- 65% of supplemented infants were breastfeeding at 6 months, vs 73% who were not supplemented:
- Absolute difference, −12% (95% CI, –26% to 3%; P=.12).
- Relative risk with supplementation: 0.85 (95% CI, 0.69-1.04).
- 12-month results: 29.6% for supplemented infants vs 48.1% for control infants (risk difference, –18%; 95% CI, −34% to −3%).
- Factors influencing duration of breastfeeding: marital status, intended duration.
- Formula at age 1 week showed a strong association with breastfeeding outcomes:
- Risk differences at 6 months: –53.8 (95% CI, –70.9 to –36.7);
- At 12 months: –46.9 (95% CI, –60.0 to –33.9).
- Trial at 2 centers, with 164 infant-mother dyads, at risk because of low milk production, newborn weight loss, or ≥75 percentile for age.
- Outcomes by phone survey.
- Funding: Healthcare Resources and Services Administration/Maternal Child Health Bureau.
- Specific infant population enrolled, delivered at academic medical centers with strong breastfeeding support.