- Low systolic blood pressure (SBP
- No association was observed between low SBP and mortality risk in those with frailty.
Why this matters
- Findings suggest that in the absence of frailty, blood pressure targets should be considered independently of age.
- Meta-analysis of 9 observational studies (n=21,906; mean follow-up, 6 years) identified after a search across MEDLINE, EMBASE and CINAHL databases.
- Primary outcome: all-cause mortality.
- Funding: Dunhill Medical Trust, UK, and others.
- Pooled results of 6 studies demonstrated that in older adults with frailty, SBP 140 mmHg (HR, 1.02; 95% CI, 0.90-1.16; P=.74).
- In older adults without frailty, SBP 140 mmHg (HR, 0.86; 95% CI, 0.77-0.96; P=.009).
- A 10-mmHg difference in SBP was not associated with mortality in older adults with (HR, 1.02; 95% CI, 0.96-1.07) and without (HR, 1.00; 95% CI, 0.97-1.04) frailty.
- No association was observed between diastolic BP and all-cause mortality in older adults with and without frailty.
- Study did not report non-fatal outcomes.
- Variation in the criteria for hypertension diagnosis and the thresholds for treatment.