Takeaway
- Findings from this large cross-sectional study involving patients at high risk for type 2 diabetes mellitus demonstrate significant association between both long and short sleep duration with measures of obesity, independent of age, sex, ethnicity and objectively measured physical activity.
- Insulin resistance measured by leptin:adiponectin ratio, glucose levels and fasting insulin were independently associated with sleep duration.
Why this matters
- Sleep being modifiable lifestyle behaviour, incorporating and emphasising good sleep practices in structured education programmes for diabetes prevention could be beneficial.
- Occurrence of insulin resistance before dysglycaemia is identifiable.
- Association between fasting insulin and sleep duration could be clinically important.
Study design
- 2848 adults with impaired glucose regulation (fasting plasma glucose between 6.1-6.9 mmol/L and/or 2-hour glucose between 7.8-11.1 mmol/L) evaluated.
- Funding: National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care–Leicestershire.
Key results
- Short sleep (≤5.5 hours) and long sleep (≥9 hours) duration were significantly associated with higher BMI (P<.001), body weight (P<.01) and waist circumference (P<.001).
- Obesity measures were lowest for 6/7 hours sleep in a 24-hour period.
- Sleep duration was positively associated with glucose levels (P<.05), fasting insulin (P<.05) and leptin:adiponectin ratio (P<.05).
- Adiponectin levels were negatively associated with sleep duration (P<.05).
Limitations
- Sleep duration was self-reported.
- Participants not screened for obstructive sleep apnoea.
References
References
