- Inadequate sleep duration, impaired daytime function, and poor sleep quality were among the sleep problems associated with increased progression of breast cancer.
Why this matters
- Clinicians should ask patients with breast cancer about sleep problems and refer affected patients to care.
- Prospective cohort of patients with breast cancer of all stages (n=1580) at a Chinese medical center.
- Sleep problems were assessed by the self-reported Pittsburgh Sleep Quality Index.
- Progression of breast cancer was one of these events: recurrence, metastasis, death, or other newly diagnosed disease.
- Funding: National Natural Science Foundation of China.
- Median follow-up was 4.2 years.
- Increased risk of breast cancer progression was seen with these sleep problems:
- long sleep duration (>9 hours vs 6-9 hours) (HR, 4.69; 95% CI, 1.31-16.78) and short sleep duration (
- poor sleep quality (vs good) (HR, 3.08; 95% CI, 1.74-5.47); and
- impaired daytime function (vs normal) (HR, 2.49; 95% CI, 1.65-3.79).
- In stratified analysis of premenopausal patients, long sleep duration (HR, 3.17; 95% CI, 1.32-7.60) and short sleep duration (HR, 1.97; 95% CI, 1.01-3.84) increased progression, but not among postmenopausal patients.
- Observational design.
- No information on exercise as confounding factor.