Sleep problems may be tied to HPV vaccine

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Takeaway

  • An analysis of the Vaccine Adverse Event Reporting System (VAERS) suggests a possible link between human papillomavirus (HPV) vaccines and sleep problems, though the researchers emphasize that the benefits of the vaccine far outweigh the risks.

Why this matters

  • The results and a plausible mechanism involving cytokines suggest sleep disorders could be a common adverse event with HPV vaccines and should be monitored.

Study design

  • The researchers carried out a case-by-case analysis of 42,568 VAERS reports related to the HPV vaccine, spanning from 1990 to 2016.
  • Funding: The Centre of Pharmacovigilance of Regione Lombardia and the Italian Ministry of Health.

Key results

  • 2.1% of the total reports were related to sleep disorders.
  • The most commonly reported sleep problems were somnolence (364), insomnia (294), and hypersomnia (117).

Limitations

  • The study was retrospective.