- An analysis of the Vaccine Adverse Event Reporting System (VAERS) suggests a possible link between human papillomavirus (HPV) vaccines and sleep problems, though the researchers emphasize that the benefits of the vaccine far outweigh the risks.
Why this matters
- The results and a plausible mechanism involving cytokines suggest sleep disorders could be a common adverse event with HPV vaccines and should be monitored.
- The researchers carried out a case-by-case analysis of 42,568 VAERS reports related to the HPV vaccine, spanning from 1990 to 2016.
- Funding: The Centre of Pharmacovigilance of Regione Lombardia and the Italian Ministry of Health.
- 2.1% of the total reports were related to sleep disorders.
- The most commonly reported sleep problems were somnolence (364), insomnia (294), and hypersomnia (117).
- The study was retrospective.