- The receipt of postoperative radiotherapy (PORT) is associated with significantly better local recurrence-free survival (LRFS) and OS in patients with stage III-pN2 NSCLC.
Why this matters
- These findings suggest better survival with PORT than reported in a previous meta-analysis, likely because of improved RT techniques that have decreased risk for cardiac and pulmonary toxicity.
- 183 patients with resected stage III-pN2 NSCLC received postoperative chemotherapy and radiotherapy (POCRT; n=78) or postoperative chemotherapy (POCT; n=105).
- Funding: Hunan Youth Talent Project and Fundamental Research Funds for the Central Universities.
- Median and 2-year LRFS were significantly higher with POCRT vs POCT:
- 29 vs 17 months.
- 62.1% vs 35.1% (P<.001>
- Median and 2-year OS were significantly better with POCRT vs POCT:
- 34 vs 29 months.
- 78.3% vs 62.1% (P=.008).
- By pN2 subclassification, patients with multiple-station pN2±pN1 disease had the worst LRFS, and patients in the POCRT group had better LRFS (11 months in POCT vs 27 months in POCRT).
- Receipt of PORT was significantly associated with better LRFS:
- Adjusted HR, 0.499; P<.001>
- Single-center, retrospective study.