- Patients with COPD with static lung hyperinflation are >4 times more likely to develop lung cancer as patients with COPD without the disorder.
Why this matters
- Lung hyperinflation is common in patients with COPD, but there were no data on the association between the disorder and lung cancer risk.
- Recent studies suggest that COPD increases the risk for lung cancer even after controlling for smoking history.
- 848 patients with COPD with 2858 patient-years of follow-up.
- Funding: Sociedad Madrileña de Neumología y Cirugía Torácica.
- At study onset, 39.4% were current smokers and 44.8% were former smokers.
- Airflow limitation was mild in 14.1%, moderate in 52.2%, severe in 27.1%, and very severe in 6.6%.
- 2.9% were diagnosed with lung cancer, 88% of whom had NSCLC and 12% SCLC.
- After multivariable analysis, static hyperinflation, defined by a functional residual capacity greater than 120% predicted, was an independent risk factor for lung cancer (aHR, 4.617; P=.049).
- Overall, 5.5% were diagnosed with cancer of any origin.
- Hyperinflation was an independent risk factor for cancer of any origin on univariate analysis, but not multivariable analysis.
- Retrospective, single-center study with an all-white and mostly male cohort.