Statin use tied to lower breast cancer mortality in Swedish cohort

  • Borgquist S & al.
  • BMC Cancer
  • 11 Jan 2019

  • curated by Miriam Davis, PhD
  • Univadis Clinical Summaries
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Statin use before and after breast cancer diagnosis was associated with a 23% and 17% lower risk for breast cancer-related mortality, respectively, in a nationwide Swedish cohort.

Why this matters

  • This large observational cohort has more power than most prior studies to detect an inverse association between statin use and breast cancer mortality.
  • This study contributes to a large body of observational evidence, but before suggesting that statins be prescribed for patients with breast cancer, a randomized controlled trial is needed.

Study design

  • Nationwide retrospective observational cohort (n=20,559 diagnosed with breast cancer) from the Swedish Cancer Registry (2005-2008).
  • Statin use was obtained from the Swedish Prescription Registry.
  • Mortality was obtained from the national cause-of-death registry.
  • Funding: European Council; Swedish Research Council; Swedish Cancer Foundation.

Key results

  • Median follow-up was 61.6 months; 2669 breast cancer-related deaths.
  • Simvastatin was the most frequently (82%-93%) prescribed statin.
  • Prediagnostic statin use:
    • Regular use of statins (vs non- or irregular use) was associated with 23% lower risk for breast cancer-related mortality (HR, 0.77; P=.014).
    • High statin use (vs nonuse) was associated with 16% lower risk for breast cancer-related mortality (HR, 0.84; P=.022).
  • Postdiagnostic statin use:
    • Statin use (vs nonuse) was associated with 17% lower risk for mortality (HR, 0.83; P=.001).

Limitations

  • Observational design.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

Submit