- Adverse experiences with statins are common, and this survey uncovers avenues for clinicians to support patients in better adherence.
- The survey goes beyond muscle-related side effects and includes cognitive and behavioral assessments.
Why this matters
- 1 in 5 patients discontinues statins because of adverse effects.
- New guidelines recommend high-intensity statins for most high-risk patients, but low adherence can be an obstacle to effectiveness.
- Patients wanted to continue their statins for the following reasons:
- Avoiding heart attack
- Avoiding stroke
- Lowering cholesterol
- Clinician recommendation
- Of the 22.1% who discontinued, being bothered by or intolerant of side effects were the main reasons.
- These patients also had higher symptom severity scores (P<.001 and impact severity scores vs those who continued.>
- They also cited too much interference in daily life and viewing side effects risk as greater than the risk for cardiovascular disease if they stopped.
- Patients could avoid discontinuation with dose reduction or switching, and fewer of those who discontinued had tried this option.
- 3-stage survey of 1500 people who had taken a statin in the past 2 years and had ≥1 statin-related symptom.
- Funding: Amgen Inc.
- Respondents were mostly white, non-Hispanic.