- A high number of cerebral microbleeds (CMBs) on MRI is associated with symptomatic intracerebral hemorrhage (sICH) in patients with stroke treated with intravenous thrombolysis (IVT).
Why this matters
- sICH is common after IVT, but hard to predict.
- sICH rates were similar in patients with and without CMBs (5.8% vs 3.5%; P=.27).
- Inhospital mortality rates were similar in patients with and without CMBs (6.8% vs 5.6%; P=.65).
- sICH rates were significantly higher in patients with >10 CMBs (30%; P<.001).
- The presence of >10 CMBs was associated with sICH in multivariate analysis (OR, 13.4; P=.0004).
- 672 patients with stroke treated with IVT, 103 with CMBs on MRI, were analyzed for risk for sICH.
- Funding: None disclosed.
- MRI results not validated by pathology.
- No non-IVT control group.