- Patients with transient ischaemic attack (TIA)/ischaemic stroke with coexisting cardiovascular disease (CVD) are at an increased risk for coronary events and recurrent ischaemic stroke compared with those without coexisting CVD.
- The risk is higher particularly in those aged
Why this matters
- Findings suggest that intensive lipid-lowering therapy may reduce the risk for recurrent events; however, the benefits from increased anti-thrombotic treatment might be offset by an increased risk for extracranial bleeding, particularly in older patients.
- This population-based study included 2555 patients with TIA or ischaemic stroke who were treated according to the current secondary prevention guidelines.
- Funding: National Institute for Health Research and others.
- 640 (25.0%) patients had a history of coexisting CVD.
- Patients with coexisting CVD vs those without had a higher 10-year risk of:
- coronary events (22.8% vs 7.1%; P<.001 adjusted hr ci>
- recurrent ischaemic stroke (31.5% vs 23.4%; P=.0049; aHR, 1.23; 95% CI, 0.99-1.53), particularly in patients aged
- major ischaemic vascular events (45.1% vs 28.7%; P<.001 ahr ci>
- Results may not be generalisable as only white British population was included.