Takeaway
- This study provides evidence of a correlation between plasma homocysteine (Hcy) level and morning BP surge (MBPS) in patients with acute ischaemic stroke.
- This finding established a link between these two cardio-cerebrovascular risk factors.
Why this matters
- Considerable researches suggest that high Hcy level is associated with ischaemic stroke risk. Ambulatory blood pressure monitoring (ABPM) parameters have also been shown associated with cardio-cerebrovascular events.
- However, the relationship between Hcy and ABPM parameters remains unclear in patients with acute ischaemic stroke.
Study design
- This study assessed 60 patients with acute ischaemic stroke who received ABPM from March 2014 to October 2014.
- MBPS, ambulatory arterial stiffness index (AASI), BP variability and night dipping patterns.
- Funding: National Natural Science Foundation of China and others.
Key results
- Mean age of the patients was 63.85±10.91 years.
- Patients in the top quartile of Hcy level showed a higher level of prewaking (OR, 1.056; 95% CI, 1.006-1.109; P=.028) and sleep-trough MBPS (OR, 1.057; 95% CI, 1.005-1.112; P=.030) vs patients in the lower 3 quartiles.
- After adjustment, linear regression analysis data indicated significant association of prewaking (r=0.356; P=.022) and sleep-trough MBPS (r=0.365; P=.017) with Hcy levels.
- No significant association was seen between Hcy level and AASI (P=.840), BP variability (P=.289) or night dipping patterns (P=.127).
Limitations
- Small sample size.
References
References
