Stroke risk increased in COPD with previous exacerbation
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Patients with COPD with previous exacerbation (COPDe) had higher risk for stroke and poorer poststroke outcomes.
Why this matters
Patients with COPDe may warrant additional monitoring and stroke prevention strategies.
Incidence of stroke was higher in patients with COPDe than those without COPD (7.6 vs 5.8 per 1000 person-years; P<.0001).
Stroke risk was not increased in patients with COPD without exacerbation (COPDne).
Association between COPDe and stroke risk was significant in males (HR, 1.37) and patients aged 50-69 y (HR, 1.44).
Probability of stroke at 1, 5, and 10 y postexacerbation was 1%, 4%, and 8%, respectively. Compared with those without COPD, probability of stroke was increased in COPDe (P<.0001), but not in patients with COPDne.
Patients with COPDe had higher risk for poststroke mortali...