Stroke risk increased in COPD with previous exacerbation

Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Patients with COPD with previous exacerbation (COPDe) had higher risk for stroke and poorer poststroke outcomes.

Why this matters

  • Patients with COPDe may warrant additional monitoring and stroke prevention strategies.

Key results

  • Incidence of stroke was higher in patients with COPDe than those without COPD (7.6 vs 5.8 per 1000 person-years; P<.0001). 
  • Stroke risk was not increased in patients with COPD without exacerbation (COPDne). 
  • Association between COPDe and stroke risk was significant in males (HR, 1.37) and patients aged 50-69 y (HR, 1.44). 
  • Probability of stroke at 1, 5, and 10 y postexacerbation was 1%, 4%, and 8%, respectively. Compared with those without COPD, probability of stroke was increased in COPDe (P<.0001), but not in patients with COPDne. 
  • Patients with COPDe had higher risk for poststroke mortality (OR, 1.34), epilepsy (OR, 1.43), and pneumonia (OR, 1.50) compared with those without COPD.

Study design

  • Retrospective cohort study of 1918 patients with COPDe, 3836 with COPDne, and 7672 without COPD. 
  • Funding: Shuang Ho Hospital, Taipei Medical University; Taiwan Ministry of Science and Technology and Ministry of Health and Welfare.

Limitations

  • Insurance claims data. 
  • Absence of information on sociodemographics, lifestyle, pulmonary function tests, BMI, and biomedical measures.