- Patients with COPD with previous exacerbation (COPDe) had higher risk for stroke and poorer poststroke outcomes.
Why this matters
- Patients with COPDe may warrant additional monitoring and stroke prevention strategies.
- Incidence of stroke was higher in patients with COPDe than those without COPD (7.6 vs 5.8 per 1000 person-years; P<.0001).
- Stroke risk was not increased in patients with COPD without exacerbation (COPDne).
- Association between COPDe and stroke risk was significant in males (HR, 1.37) and patients aged 50-69 y (HR, 1.44).
- Probability of stroke at 1, 5, and 10 y postexacerbation was 1%, 4%, and 8%, respectively. Compared with those without COPD, probability of stroke was increased in COPDe (P<.0001), but not in patients with COPDne.
- Patients with COPDe had higher risk for poststroke mortality (OR, 1.34), epilepsy (OR, 1.43), and pneumonia (OR, 1.50) compared with those without COPD.
- Retrospective cohort study of 1918 patients with COPDe, 3836 with COPDne, and 7672 without COPD.
- Funding: Shuang Ho Hospital, Taipei Medical University; Taiwan Ministry of Science and Technology and Ministry of Health and Welfare.
- Insurance claims data.
- Absence of information on sociodemographics, lifestyle, pulmonary function tests, BMI, and biomedical measures.