Study highlights maternal risk factors for cardiovascular disease

  • Sia WW & al.
  • J Obstet Gynaecol Can
  • 3 Jul 2019

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • Hypertensive disorders of pregnancy were the most important maternal risk factors for cardiovascular disease (CVD) later in life.
  • Women with coronary artery disease (CAD) were more likely to have maternal complications such as gestational hypertension in addition to other conventional vascular risk factors.

Why this matters

  • Clinicians should consider sex-specific risk stratifications that include pregnancy history when assessing women with, or at risk for, CAD.

Study design

  • This retrospective, age-matched, case-control study included 244 women with CAD (cases) and 246 without CAD (control group) based on their obstetrical history and outcomes, and also on their traditional CV risk factors.
  • Funding: None disclosed.

Key results

  • Women with CAD vs those without had significantly higher rates of:
    • gestational hypertension (OR, 3.34; 95% CI, 1.03-10.9; P=.0443),
    • dyslipidaemia (OR, 5.38; 95% CI, 2.70-10.7; P<.0001>
    • hypertension (OR, 2.40; 95% CI, 1.23-4.70; P=.0107),
    • diabetes (OR, 2.32; 95% CI, 1.07-5.01; P=.0325) and
    • smoking (ORs, current: 4.82 [95% CI, 1.66-14.00]; P=.0039 and former: 2.86 [95% CI, 1.43-5.71]; P=.0029).
  • Compared with those without CAD, women with CAD had a higher rate of pre-eclampsia, but the difference was not statistically significant (9.8% vs 5.4%; P=.065).

Limitations

  • Retrospective design.
  • Each case was matched with only 1 control.

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