Takeaway
- Hypertensive disorders of pregnancy were the most important maternal risk factors for cardiovascular disease (CVD) later in life.
- Women with coronary artery disease (CAD) were more likely to have maternal complications such as gestational hypertension in addition to other conventional vascular risk factors.
Why this matters
- Clinicians should consider sex-specific risk stratifications that include pregnancy history when assessing women with, or at risk for, CAD.
Study design
- This retrospective, age-matched, case-control study included 244 women with CAD (cases) and 246 without CAD (control group) based on their obstetrical history and outcomes, and also on their traditional CV risk factors.
- Funding: None disclosed.
Key results
- Women with CAD vs those without had significantly higher rates of:
- gestational hypertension (OR, 3.34; 95% CI, 1.03-10.9; P=.0443),
- dyslipidaemia (OR, 5.38; 95% CI, 2.70-10.7; P<.0001),
- hypertension (OR, 2.40; 95% CI, 1.23-4.70; P=.0107),
- diabetes (OR, 2.32; 95% CI, 1.07-5.01; P=.0325) and
- smoking (ORs, current: 4.82 [95% CI, 1.66-14.00]; P=.0039 and former: 2.86 [95% CI, 1.43-5.71]; P=.0029).
- Compared with those without CAD, women with CAD had a higher rate of pre-eclampsia, but the difference was not statistically significant (9.8% vs 5.4%; P=.065).
Limitations
- Retrospective design.
- Each case was matched with only 1 control.
References
References
