- The Nurses Health Study (NHS) II failed to find an association between high dietary gluten and new-onset psoriasis, psoriatic arthritis (PsA), or atopic dermatitis.
Why this matters
- Findings do not support gluten as a modifiable risk factor for psoriasis, PsA, or atopic dermatitis.
- The NHS II prospective cohort study included 85,185 participants for psoriasis, 85,324 for PsA, and 63,443 for atopic dermatitis analyses.
- Dietary gluten was calculated from a Food Frequency Questionnaire given every 4 years (1991-2015 for psoriatic disease, 1995-2013 for atopic dermatitis).
- To determine disease outcome, participants were asked about year of diagnosis every few years but no later than 2013, and disease onset was validated by medical records.
- Funding: NIH; Brown University; Regeneron; Sanofi.
- Multivariate analysis did not find an association between high (vs low) quintile of dietary gluten and:
- Psoriasis: HR, 1.15; 95% CI, 0.98-1.36.
- PsA: HR, 1.12; 95% CI, 0.78-1.62.
- Atopic dermatitis: HR, 0.91; 95% CI, 0.66-1.25.
- Observational design.
- No confirmation of dietary gluten.
- No assessment of gluten and disease severity.