Study nixes link between nuts and pancreatic cancer

  • Obón-Santacana M & al.
  • Int J Cancer
  • 20 May 2019

  • curated by Miriam Davis, PhD
  • Univadis Clinical Summaries
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Takeaway

  • High consumption of nuts (including seeds) was not associated with the development of pancreatic ductal adenocarcinoma (PDAC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

Why this matters

  • PDAC is increasing in incidence.
  • Primary prevention of PDAC is a long-sought goal, given that 5-year survival is the worst (

Study design

  • Prospective study of 476,160 participants assessed for PDAC.
  • Nut intake (including seeds) was obtained at baseline by a country-specific dietary questionnaire in 10 European countries (23 research centers).
  • Funding: European Commission; International Agency for Research on Cancer; others.

Key results

  • 1283 PDAC cases were identified after a mean follow-up of 14 years.
  • No association was seen between high (vs no) nut consumption and PDAC (HR, 0.89; 95% CI, 0.72-1.10; Ptrend=.70).
  • No effect-measure modification was found in stratified analyses (according to heavy alcohol consumption, diabetes, smoking status, BMI, sex, geographic region, or country intake).

Limitations

  • Nut and seed consumption only assessed at baseline.
  • Observational design.
  • Study could not adjust models for all established PDAC risk factors (i.e., family history, blood group, and chronic pancreatitis).