Study supports link between insulin resistance and high concentrations of oxidized LDL

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Insulin metabolism has been previously linked to oxidized low-density lipoproteins (ox-LDL), but corroborating intervention studies are lacking. A recent weight reduction intervention study adds supportive evidence of the connection between insulin metabolism and oxidized LDL, possibly contributing to the higher incidence of atherosclerotic cardiovascular diseases among diabetic patients.


  • Men of 35-50 years of age, BMI ≥ 30 kg/m2, and waist circumference > 100 cm were recruited via newspapers in Tampere, Finland
  • A 2-month weight reduction was followed by 6-month diet and exercise counselling and a 2-year follow-up period
  • Ox-LDL was estimated as the presence of oxidized lipids in LDL
  • Homeostasis model assessment of insulin resistance (HOMA-IR), ox-LDL, and ratio of ox-LDL and high-density lipoprotein cholesterol (ox-LDL/HDL-c) were used as the main outcome measures
  • Detected changes in HOMA-IR were strikingly similar to those in ox-LDL and ox-LDL/HDL-c
  • Compared to the first HOMA-IR quartile, the fourth quartile had 23%-51% higher concentrations in ox-LDL and ox-LDL/HDL-c at all time points (P < 0.05 for all)