Study supports link between insulin resistance and high concentrations of oxidized LDL

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Insulin metabolism has been previously linked to oxidized low-density lipoproteins (ox-LDL), but corroborating intervention studies are lacking. A recent weight reduction intervention study adds supportive evidence of the connection between insulin metabolism and oxidized LDL, possibly contributing to the higher incidence of atherosclerotic cardiovascular diseases among diabetic patients.

Method

  • Men of 35-50 years of age, BMI ≥ 30 kg/m2, and waist circumference > 100 cm were recruited via newspapers in Tampere, Finland
  • A 2-month weight reduction was followed by 6-month diet and exercise counselling and a 2-year follow-up period
  • Ox-LDL was estimated as the presence of oxidized lipids in LDL
  • Homeostasis model assessment of insulin resistance (HOMA-IR), ox-LDL, and ratio of ox-LDL and high-density lipoprotein cholesterol (ox-LDL/HDL-c) were used as the main outcome measures
Results
  • Detected changes in HOMA-IR were strikingly similar to those in ox-LDL and ox-LDL/HDL-c
  • Compared to the first HOMA-IR quartile, the fourth quartile had 23%-51% higher concentrations in ox-LDL and ox-LDL/HDL-c at all time points (P < 0.05 for all)