- Results from a Turkish study suggest that antibody-negative subclinical hypothyroidism is associated with increased risk for pregnancy loss and other negative pregnancy outcomes.
Why this matters
- The association between subclinical hypothyroidism and pregnancy outcomes is controversial.
- Findings support routine screening at the first antenatal visit.
- Compared with euthyroid pregnant women, those with subclinical hypothyroidism showed increased risks for:
- Pregnancy loss (8.2% vs 3.3%; OR, 2.583; P<.001>
- Impaired glucose tolerance (6% vs 3.4%; OR, 1.952; P<.001>
- Hypertensive pregnancy disorder (7.4% vs 5.4%; OR, 1.476; P=.004).
- Neonatal intensive care unit admission (3.1% vs 2.1%; OR, 1.620; P=.019).
- Placenta previa (1.1% vs 0.1%; OR, 12.581; P<.001>
- Cesarean delivery (34.7% vs 31.4%; OR, 1.263; P=.002).
- 930 pregnant women with untreated, antibody-negative subclinical hypothyroidism and 7986 euthyroid pregnant women were analyzed for pregnancy outcomes.
- Funding: None disclosed.
- Retrospective study.