Subclinical hypothyroidism linked to adverse pregnancy outcomes

  • Cakmak BD & al.
  • J Obstet Gynaecol Res
  • 22 Jan 2019

  • curated by Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Results from a Turkish study suggest that antibody-negative subclinical hypothyroidism is associated with increased risk for pregnancy loss and other negative pregnancy outcomes.

Why this matters

  • The association between subclinical hypothyroidism and pregnancy outcomes is controversial.
  • Findings support routine screening at the first antenatal visit.

Key results

  • Compared with euthyroid pregnant women, those with subclinical hypothyroidism showed increased risks for:
    • Pregnancy loss (8.2% vs 3.3%; OR, 2.583; P<.001>
    • Impaired glucose tolerance (6% vs 3.4%; OR, 1.952; P<.001>
    • Hypertensive pregnancy disorder (7.4% vs 5.4%; OR, 1.476; P=.004).
    • Neonatal intensive care unit admission (3.1% vs 2.1%; OR, 1.620; P=.019).
    • Placenta previa (1.1% vs 0.1%; OR, 12.581; P<.001>
    • Cesarean delivery (34.7% vs 31.4%; OR, 1.263; P=.002).

Study design

  • 930 pregnant women with untreated, antibody-negative subclinical hypothyroidism and 7986 euthyroid pregnant women were analyzed for pregnancy outcomes.
  • Funding: None disclosed.

Limitations

  • Retrospective study.