Subclinical hypothyroidism tied to hypertensive disorders of pregnancy

  • Front Endocrinol

  • International Clinical Digest
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Takeaway

  • Subclinical hypothyroidism (SCH) is associated with hypertensive disorders of pregnancy (HDP), specifically during the first 2 trimesters.

Why this matters

  • Study suggests that routine thyroid function screening during pregnancy may be justified.

Key results

  • Overall incidence of SCH was 2.68%.
  • SCH was associated with HDP in adjusted analysis (OR, 4.04; P=.000).
  • In subgroup analysis, SCH was associated with HDP when thyroid function was screened in the first trimester (OR, 9.69; P=.01) or second trimester (OR, 3.66; P=.03) but not during the preconception period or third trimester.
  • SCH was not significantly associated with gestational diabetes, intrahepatic cholestasis of pregnancy, preterm labor, placenta previa, preterm premature rupture of membranes, fetal distress, fetal death, Apgar 4000 g in adjusted analysis.

Study design

  • 7587 people were screened for thyroid status and associations with adverse perinatal outcomes.
  • Funding: National Natural Science Foundation of China, National Key R&D Program of China, Shanghai Municipal Health Bureau.

Limitations

  • Retrospective study design.
  • Detailed treatment data not available.

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