Subclinical hypothyroidism tied to increased CVD risk and all-cause mortality

  • Moon S & al.
  • Thyroid
  • 6 Jul 2018

  • curated by Pavankumar Kamat
  • UK Medical News
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

A recent meta-analysis, published in the journal Thyroid, suggests that subclinical hypothyroidism (SCH) could have an association with elevated cardiovascular disease (CVD) risk and all-cause mortality, especially among those already with a high CVD risk.

Researchers performed a meta-analysis of 35 studies (n=555,530), identified through a literature search on the PubMed and Embase databases.

Overall, SCH was found to have a modest association with CVD (relative risk [RR], 1.33; 95% CI, 1.14-1.54) and all-cause mortality (RR, 1.20; 95% CI, 1.07-1.34) and the association only held true for individuals aged

The current American guidelines suggest treatment for SCH in individuals with thyroid-stimulating hormone levels ≥10 mIU/L; symptoms suggestive of hypothyroidism; a positive test for antibodies to thyroid peroxidase or evidence of atherosclerotic CVD, heart failure or CVD risk factors. According to the authors, the study findings could provide a new perspective in identifying a subgroup of individuals with SCH based on CVD risk that could benefit from treatment, and can subsequently contribute crucial evidence to support the current guidelines.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

Submit