Access to the full content of this site is available only to registered healthcare professionals.
Register to read more
In subcortical vascular dementia, amyloid burden, independently or interactively with small vessel disease, contributed to longitudinal cognitive decline, and amyloid deposition was the strongest poor prognostic factor.
This longitudinal cohort study enrolled 61 patients with subcortical vascular dementia from 2 tertiary referral centers.
Patients had baseline MRI and 11C-Pittsburgh compound B (PiB) PET (to detect amyloid) and annual neuropsychological testing for 3 years.
Generalized estimation equations allowed controlling for age, sex, education, APOE4, and follow-up interval.
PiB positivity predicted faster decline in attention, visuospatial, visual memory, and global cognition function.